The significance of exosomes in intracellular communication make them an important vehicle to deliver a variety of drugs throughout the body.
Exosomes are everywhere in your circulatory system and naturally rush to the site of damage or disease passing through biological barriers that small molecules cannot. As such, exosomes are increasingly being studied as delivery vehicles for small molecule therapies, proteins, RNA, DNA and potentially new CRISPR technologies.
Exosomes offer many drug delivery benefits:
Able to cross the blood-brain barrier
No immune rejection response
Capable of repeat dosing
Categorized as a biologic by the FDA
Aruna’s neural derived and neural specific exosomes have demonstrated the ability to be administered intravenously and in repeated doses have shown no adverse side effects and demonstrate brain-blood barrier penetration in both the injured and uninjured brain with neural cell selectivity. This platform holds the potential to efficiently transport rich cargos of proteins, lipids, DNA and RNAs across the blood brain barrier and deliver treatments for a diverse range of neurological disorders.